gingival stem/progenitor cells mediated periodontal tissue engineering/regeneration: the regenerative-inflammatory axis
Stem/progenitor cell-based therapies hold an enormous therapeutic potential, improving the lives of patients in various medical disciplines. Gingival mesenchymal stem/progenitor cells (G-MSCs) possess notable periodontal reparative/regenerative potentials, with resistance to inflammatory stimuli, and local immunomodulatory properties. Latest investigations outlined an individual G-MSCs-TLRs’ expression profile, and defined two TLR-generated immunomodulatory phenotypes in G-MSCs challenged by TLR-agonists. Yet, apart from the fact that G-MSCs obtained from inflamed gingival tissues presented a differentiation/regenerative potential comparable to G-MSCs form uninflamed tissues, recent studies outlined positive short-term stimulatory effects of controlled inflammatory micro-environments on the proliferation and differentiation of G-MSCs.The aim of the present lecture is to give an insight on the current evidence and challenges linked to the use of G-MSCs, in a tissue-engineering scheme, for periodontal tissue regeneration and our current investigation results and understanding on their regenerative-inflammatory axis involved.